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Early animal evolution: A morphologist's view

Hum Mol Genet 10:145152 Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntingtons disease mutation

As PUFAs are essential for membrane fluidity and permeability, we hypothesize that saturation degree imbalances could play a pivotal role in membrane destabilization processes leading to cell apoptosis