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Currently, most of the treatments used to treat COVID-19 are systemic, but recently, there has been a strong interest in establishing a non-invasive nasopharyngeal route for inhalation and delivery by inhalation to treat SARS-CoV-2 infection

163,164 However, ineffective clearance of apoptotic neutrophils results in necrosis and the subsequent release of toxic granulocytes and DAMPs into the extracellular space, exacerbating the local inflammatory response and tissue damage