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By day 12, a chest CT showed small bilateral pleural effusions and partial improvement in bilateral pneumonia, confirming the treatments effectiveness (Figures 2A1, A2)

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Clinical data of these vaccines showed that combination therapy of Tat immunogens with ART drugs could increase the number and function of CD4+ and CD8+ T-cells, and reduce pro-viral load.1 Conclusions In conclusion, development of an effective HIV-1 therapeutic vaccine needs the rational design of immunogens to redirect responses to multiple known protective and un-mutated parts of the virus that cover distinct HLAs and HIV-1 diversity