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Consequently, dysregulation of GSH production is seen in a number of medical conditions, such as renal failure 20 , liver injury 21 , diabetes, neurological diseases 22 , organ fibrosis 23 , and cardiovascular disease 24

Moreover, targeted nanocarriers can be engineered to interact with specific immune or stromal cell subsets, such as dendritic cells, macrophages, or tumor-associated fibroblasts, reprogramming the local immune landscape toward an immunostimulatory phenotype

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Although these values already indicate oxidative or reductive stress conditions, the normal physiological range will be much narrowed in between these values