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Given that glial and neuronal cells undergo aging-related changes, including SASP, alterations in extracellular matrix composition, mitochondrial DNA release, and activation of inflammatory signaling pathways, shifts in membrane or lipid environments may influence these processes by modulating LLPS and domain dynamics

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In neuroprotection studies, guided progression analysis using Cirrus HD-OCT offers a trend-based statistical approach that may replace perimetry as the primary outcome (101)