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10.1016/j.cell.2007.06.049 Cell 11 LeeA

It can, but the evidence is weaker than the label-dose weight-loss evidence

However, it should be noted that excessive vitamin B6 (pyridoxine) ingestion in the form of vitamin B16-12 combination tablets may also cause irreversible neurotoxicity (171)

Specifically, folic acid can correct the anemia (large red blood cells) caused by B12 deficiency, but it cannot prevent the nerve damage that B12 deficiency causes