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Ito, Wilson R

Next, an insulin-induced interaction between phosphorylated insulin receptor substrate 1 and its target (the N-terminal SH2 domain of PI 3-kinase) was observed in mammalian cells by luciferase reconstitution by the naturally split Ssp DnaE intein[100]

[100] using circulating endothelial progenitors named endothelial colony-forming cells, accelerated endothelial senescence in smokers and patients with COPD was shown compared with healthy controls

In addition, JMJD6 promotes the maintenance of mHSC self-renewal by suppressing OXPHOS and other detrimental mechanisms, such as p53 stabilization 108