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Another is the identification of novel biomarkers that might offer even more precise indicators of response, allowing for hyper-personalized 5-Amino-1MQ dosage adjustments in future research

The Cochrane Collaboration, Chichester, UK: John Wiley & Sons

In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity

Accessed 6/23/2021, Hirsch AG, Poulsen MN, Nordberg C, et al