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Common symptoms of rheumatoid arthritis include: Joint pain that is symmetrical (affecting both sides of the body) Morning stiffness that lasts longer than 30 minutes Swollen joints , especially in the hands, wrists, and knees Fatigue and low energy that feels constant or unrelenting Warm or tender joints , particularly after periods of rest Reduced range of motion or difficulty with fine motor tasks Muscle aches that are not related to exercise or injury Low-grade fevers or flu-like symptoms that come and go Weight loss that is unintentional and accompanied by fatigue Depression or mood changes , often related to chronic pain During menopause , the loss of estrogens protective effects can make RA symptoms worse

Once intracellular lactate is sufficient to induce CD4 + T cell phenotype transformation, RORT-dependent IL-17 expression via activation of the PKM2-STAT3 axis would be initiated, confirming lactate as a critical mediator in inflammation-related diseases, including RA

(2017) demonstrated that isolated phospholipids from rat liver mitochondria from animals on ad libitum diet present an increased content of lipoperoxides and higher polarization