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You should seek immediate medical attention if: The numbness is sudden and severe, especially if it occurs with chest pain, shortness of breath, or dizziness, as this could indicate a heart attack or stroke

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The collagen remodeling cycle completes its first full pass, and the cumulative effect of new fiber synthesis becomes visible as improved firmness, reduced sagging in the lower face and neck, and a measurable difference in skin density

It is usually injected intramuscularly into a large muscle, such as the buttock or upper arm