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Seneff and Kyriakopoulos, 2025b)

GHRP-2 is notable for producing significant ACTH and cortisol co-release a feature shared with GHRP-6 and Hexarelin and absent from the more selective Ipamorelin making it a valuable research tool for studying HPA axis interactions with the ghrelin receptor system at high GHS-R1a stimulation levels

These changes impair mucus barrier function, disrupt lectin-sugar interactions, disturb host-microbe communication, and weaken mucosal immunity, collectively promoting IBD pathogenesis (79)