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They found low vitamin B 12 levels in those patients as well, which suggests there may be some association between B 12 and immune function

Additionally, CD38 is upregulated in the heart following ischemiareperfusion injury, the CNS in a variety of neurodegenerative and neuroinflammatory diseases, in tumorigenesis, and in muscle, liver and articular cartilage during aging 11,31,53,54