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Emerging studies have clearly demonstrated that hypoxia regulates the critical metabolic, developmental, and survival pathways in TNBC, which include glycolysis and angiogenesis

Yishen Chuchan Decoction improves PD by enhancing cell viability, reducing apoptosis, and suppressing inflammation and oxidative stress through the inhibition of the p38 MAPK pathway (Di et al

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However, this approach is notably less effective for individuals with chronic forms of thiamine deficiency-related disorders involving encephalopathies (see the section Wernicke Encephalopathy) (113) or TPK1 deficiencies