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For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)

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20% of patients with NASH develop cirrhosis and have a high risk of hepatocarcinoma

Chen YH, Chen HL, Fan HC, Tung YT, Kuo CW, Tu MY, Chen CM (2020) Anti-inflammatory, antioxidant, and antifibrotic effects of kefir peptides on salt-induced renal vascular damage and dysfunction in aged stroke-prone spontaneously hypertensive rats