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similarly, patients with a major depressive or a bipolar disorder while performing a n -back working memory task failed to deactivate the medial prefrontal cortex (Rodrguez-Cano et al., 2017)

If additional validation of acetylcarnitine is carried out in a follow-up study, taking into account the larger sample size, controlled subject variables, antidepressant type, and heterogeneity due to pharmacomechanism, the potential of acetylcarnitine as a biomarker for diagnosing depression and remission status will be further elucidated