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Meanwhile, the prodrug of triptolide, has been developed in clinical trials for patients with advanced solid tumors (NCT03129139) and refractory pancreatic malignancy (NCT03117920 and NCT04896073)

Second, the exposure to ketone bodies produced during nutritional ketosis provides unique cellular and molecular benefits that may protect and repair lymphatic tissues by providing a protective buffer against the unavoidable lymphatic injury experienced with conventional cancer treatments

The proposal that V may be an essential element for humans, while not discarded (Chellan & Sadler, 2015), has not gained wide support

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