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Typical daily range: 100300 mcg once daily (gradual titration)

Concurrent dosing reduces efficacy by creating NAD+ demand spikes and competitive receptor saturationtiming separation is the critical variable for synergy

Safety assessment The subjects vital signs (including pulse, blood pressure, and forehead temperature) were measured within 2 h before and 2, 4, 8, 24, and 48 h after each cycle of drug administration, with an allowable time window of 1 h for vital sign measurements, and reference values ranging from (including borderline values): systolic blood pressure: 85139 mmHg