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mARC is present in great quantities in the kidneys and the liver and thus actively participates in the detoxification of N -hydroxylated substrates [1]

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STORY AT-A-GLANCE Japanese professor Toru Miyazaki has discovered a potential trigger for feline chronic kidney disease (CKD) that involves the protein AIM (apoptosis inhibitor of macrophage), also known as CD5-like (CD5L) AIM is a secreted protein in the blood that supports kidney health by identifying, destroying, and removing dead cells and other debris that accumulate in the body In many cats, it seems the AIM protein cant do its job properly because it binds too tightly to IgM [immunoglobulin M] antibodies, which impedes its ability to dissociate from the antibodies and attach to the problematic debris to initiate the cleansing process Miyazaki has collaborated with both an ultraprocessed pet food producer and a pharmaceutical company in Japan to develop a food+drug companion therapy to prevent and treat CKD in cats