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cloudiness, particles, or loss of the blue tint are reasons to discard the vial

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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing

Erring on the side of caution with periodic assessment provides peace of mind and early warning of any unexpected effects