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In vitro studies have demonstrated that overexpression of Angiogenin, a RNase associated with familial ALS, activates NRF2 which protects astrocytes from oxidative stress (Hoang et al., 2019) and curcumin mediated NRF2 induction ameliorates mitochondrial dysfunction (Lu et al., 2012)

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This over-activation depletes NAD + reserves, contributing to metabolic reprogramming that favors glycolysis over oxidative phosphorylation

PQQ, as an auxiliary factor, can promote mitochondrial regeneration in aging cells, increase the activity of related enzymes, and stimulate mitochondrial growth