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doi: 10.1634/theoncologist.2013-0061

Thus, Nrf2 activates both the oxidative and nonoxidative PPP to increase NADPH and nucleotide production 51

One study indicated that down-regulating the expression of the pro-apoptotic factor Bax and reducing the Bax/Bcl-2 ratio effectively mitigated degenerative lesions in dopaminergic neurons associated with PD (Yang et al., 2025)

CD8 + T cells with or without ectopic expression of GPX4 were subsequently treated ex vivo in the presence or absence of A2ARi before being transferred into MC38-bearing mice