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369 SoreqL.RoseJ.SoreqE.HardyJ.TrabzuniD.CooksonM.et al (2017)

Statins inhibit Rac1 activity to reduce superoxide production and were shown to be protective against AF in preclinical models [Figure 2] [72,73]

2 Core molecular regulatory network of ferroptosis The occurrence of ferroptosis is the result of a dynamic balance between pro-ferroptotic forces (iron homeostasis imbalance, lipid peroxidation) and anti-ferroptotic defenses (antioxidant systems)