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A direct correlation between increased metabolism of docetaxel, flutamide, paclitaxel, and mitoxantrone because of increased expression of CYP1B1 (cytochrome P450 1B1) and the onset of MDR in various cancer cells has been drawn out by researchers, as is the case with overexpression of the CYP2A6 (cytochrome P450 2A6) enzyme in breast tumour cells, whereby it is reported to enhance the metabolism of drugs like aflatoxin, cyclophosphamide, ifosfamide, and fluorouracil [54]

Grade 3 neutropenia and febrile neutropenia occurred in 42.4% and 5.3% of patients, respectively

doi:10.1016/j.envres.2013.07.005

Always talk to your doctor to adjust your dose