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Tonbridge) to the nearest 100 g, and heights were measured using a stadiometer to the nearest 0.1 cm

30(5) 2020 Esmon Publicidad doi: 10.18176/jiaci.0567 4

As it is mainly expressed in the liver and brain, human hepatocarcinoma usually present increased hTDO expression and many studies have suggested the involvement of hTDO in CNS diseases such as Alzheimers, Parkinsons and Huntingtons disease [151,152,153]

These morphological changes influence the distribution of mitochondria, potentially leading to an uneven distribution of energy supply and localized ROS accumulation