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ITB is diagnosed based on history and clinical examination findings

Gkbel et al., 2010

10.1038/jcbfm.2012.151 101 MartinK.JacksonC

At night, rising melatonin acts on MT1/MT2 receptors in various tissues to induce nighttime physiology: it promotes the onset of sleep, lowers core body temperature, slows gastrointestinal activity, and modulates metabolism to a nocturnal state