doi: 10.1038/s41591-021-01569-2 Summary Keywords COVID-19, NLRP3 inflammasome, oxidative stress, lipid peroxidation, CD14 high CD16 monocytes Citation Lage SL, Amaral EP, Hilligan KL, Laidlaw E, Rupert A, Namasivayan S, Rocco J, Galindo F, Kellogg A, Kumar P, Poon R, Wortmann GW, Shannon JP, Hickman HD, Lisco A, Manion M, Sher A and Sereti I (2022) Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 Monocytes From COVID-19 Patients
10.1371/journal.pone.0304335 62 JacksonK
Clinical Results: Based on an independent clinical study with 32 subjects after 8 weeks: Clinically proven to visibly improve uneven tone, discoloration, radiance, firmness, and elasticity 94% had visibly improved discolorations 91% had brighterlooking skin For optimal results, use morning and evening
Problem: No Visible Results After 12 Weeks Possible causes: Concentration too low for your needs Inconsistent application Product quality issues Unrealistic expectations for your age/condition Undermining factors (sun exposure, smoking, poor sleep) Solution process: Review application consistency honestly Consider increasing concentration Verify product is from reputable source Compare photos from day 1 to now (changes are often invisible day-to-day) Address lifestyle factors that counteract skincare Problem: Good Results Initially, Then Plateau Possible causes: Skin has adapted (normal) Need higher concentration or additional actives Seasonal changes affecting skin Product has lost potency Solution process: Increase concentration if currently using low percentage Add complementary active (retinoid or niacinamide) Try pulsing method: use for 3 weeks, break for 1 week, resume Check product storage and expiration Product Selection Guidelines Not all copper peptide products perform equally
