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Yasuda H, Yoshida K, Yasuda Y, Tsutsui T

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PMID 12619921) found that postmenopausal women with osteoporosis treated with growth hormone alongside HRT and calcium/vitamin D showed a 14% increase in lumbar spine bone mineral content at 4-year follow-up Elevated IGF-1 driven by GH stimulation promotes fibroblast activity, supporting collagen turnover and skin elasticity that decline with estrogen loss Administration method: Subcutaneous injection, typically administered nightly to align with the body's natural growth hormone release window during the first sleep cycle