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"Kojic acid is naturally derived as a result of fermentation from fungus and helps to brighten the skin and lessen discoloration," she explains

The pivot toward skin came from an incidental observation: patients receiving high-dose glutathione for other reasons sometimes reported skin lightening, and laboratory work showed that glutathione could inhibit tyrosinase , the rate-limiting enzyme of melanin production

Revaccination is permitted when the patient is at high risk of severe infection or likely to experience a rapid decline in antibody levels