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CuGI@CM can selectively eliminate hypoxic tumors by boosting ROS production and facilitating oligomerization of lipoylated proteins in the tricarboxylic acid cycle, and when combined with RT, it significantly enhances the therapeutic efficacy (Liu J

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202 Additional meta-analyses have also concluded that probiotics, prebiotics, and synbiotics can reduce oxidative stress, decrease inflammation, improve lipid levels, and heighten glucose metabolism in CKD patients

Through their observed neuroprotective and neurotrophic effects, associated with reductions in neuroinflammation and oxidative stress, evidence supports the use of erinacines and erinacine-containing compounds as potential therapeutics in neurodegenerative diseases and in preventing overall neurocognitive decline