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Class I (e.g., erastin, sulfasalazine (SAS)) targets xCT and cystine uptake [19, 23, 24], Class II (e.g., RSL3, ML162) targets GPX4 enzymatic activity [25], Class III (e.g., FIN56) depletes GPX4 and ubiquinone [26], and Class IV (e.g., FINO2) indirectly inhibits GPX4 while directly oxidizing iron [27,28,29]

Glial cell-derived neurotrophic factor induces enteric neurogenesis and improves colon structure and function in mouse models of Hirschsprung disease

29,32 The neutral and basic amino acid transporter (RBAT, also designated by SLC3A1 ) is another cystine transporter with possible implications in cancer development