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1 Introduction In the mid-19th century, Rudolf Virchows cellular theory concluded that all diseases, including cancer are a result of alterations in cells, resulting in an understanding of cancer as a disease of abnormal cell proliferation ( One of the major hurdles in the treatment of cancer is chemoresistance that is similar to the resistance to drugs in infectious disease ( The cancer heterogeneity is considered as a main factor in cancer drug resistance that is a result of genetic alterations caused by mutational processes ( 2 Autophagy fundamentals and molecular machinery 2.1 Autophagy basics and molecular machinery Autophagosome biogenesis is considered as a dynamic molecular process and it is a particular aspect of research ( LC3 was initially identified in the rat brain as a light chain of microtubule-associated proteins 1A and 1B, including two isoforms, LC3A and LC3B

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With respect to diagnosis of adult GHD of classical etiology, guidelines state that adult patients with structural hypothalamic/pituitary disease, surgery or irradiation in these areas, head trauma, or evidence of other pituitary hormone deficiencies are considered appropriate for acquired GHD and that idiopathic GHD as which occurs during aging requires stringent criteria to make the diagnosis

The functional importance of this antagonism is demonstrated by the finding that the loss of self-renewal caused by CHAC2 knockdown is completely rescued by the additional knockdown of CHAC1