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Cognitive impairment in multiple sclerosis

Seahorse assay results further showed that FIDAS-5 induced a dose-dependent decrease in the ECAR and a concomitant increase in the OCR, indicating both impaired glycolytic flux and enhanced mitochondrial respiration (Fig

21 BorreY

This peroxidase uses the antioxidant tripeptide glutathione (GSH) instead of thioredoxin as the physiological reductant to reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or to hydrolyze the sn-2 ester (alkyl) bond of phospholipids (phospholipase A(2) [PLA(2)] activity)