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Although the disease was stable in all patients, some of them showed remissions during treatment, but a correlation in remission occurrence and treatment were not clear.[] Also, other studies revealed no significant results due to controversial antioxidants active doses,[] whereas other reports evaluated antioxidant efficiency during remission and observed that SOD activity signiflcantly increased, but GPx activity was reduced after antioxidant treatment.[] In addition, there are some studies that were not able to report any significant differences between placebo treatment and antioxidant treatment due to closely similar clinical results.[] Furthermore, all clinical trials used far smaller medium potency antioxidants doses, a fact that again questions their effectiveness in chronic disease, such as IBD

A decrease in nitrogenase activity was observed for the CgCS strain in the KD medium culture (Fig

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Biomarker changes do not establish broad clinical benefits