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In this context, mutagenic analyses have shown that amino acid residues located on the convex face of -SNAP are not relevant for -SNAP binding to SNAREs 33 Following these findings, co-immunoprecipitation and fluorescence resonance energy transfer (FRET) studies have shown that M105I mutation (located in the convex face) does not affect the binding of -SNAP to SNARE complexes 14,15

189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level

Genome Announcements, 5(17)

For example, silver nanoparticles upregulate the level of Drp1, disrupting mitochondrial structure and function