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Age: Older patients may have slower response times Health status: Presence of comorbidities can affect treatment outcomes Lifestyle factors: Diet, exercise, and smoking status can influence efficacy Healthcare providers can tailor stem cell patch therapy better by understanding these factors

thus, only a stratification according to these factors would ensure a reliable evaluation of biologics efficacy in reducing the likelihood of developing arthritis

Tashkin DP, Celli B, Senn S, et al

This article comprehensively reviews 12 different mechanisms of cell death related to the pathogenesis of CD: apoptosis, necroptosis, pyroptosis, parthanatos, ferroptosis, autophagy-dependent cell death, cuproptosis, oxeiptosis, entotic cell death, netotic cell death, lysosome-dependent cell death, and alkaliptosis