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Retatrutide: Complication Focus TRIUMPH-4: Obesity + knee osteoarthritis (445 participants) TRIUMPH-2: Obesity + type 2 diabetes TRIUMPH-6: Weight maintenance trial Advantage: Multiple complication-specific trials could lead to broader label (obesity + OA + OSA indications)

To assess the functional implications of these microbial shifts, we employed PICRUSt and the KEGG database (see Section Caecal microbiota profiling) to predict metabolic pathway activity of caecal microbiota across the three groups (Appendix Fig