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While the number of MGDs reported in scientific literature and in clinical development (approximately 20 MGDs) remains modest, it is anticipated that this domain of TPD will expand in the coming years, driven by a deeper comprehension of the protein-protein interaction interfaces and the more rational development of new compounds 203,204

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SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), significant on 4-point MACE (0.88) and all-cause death (0.84): Heerspink SURPASS-4 kidney post-hoc

concentrations from A would also reach a higher level and remain above the target concentration for a longer period