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Laboratory studies may show evidence of massive hepatic necrosis with elevated AST, ALT, bilirubin, and prolonged coagulation times (in particular, elevated prothrombin time)

J Vasc Surg 22:155160 Chatziantoniou C, Boffa JJ, Ardaillou R, Dussaule JC (1998) Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice