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There is one small pilot study in humans (examining knee pain, where 7 of 12 participants reported sustained improvement beyond 6 months) and a 2025 safety study confirming BPC-157 was well tolerated in healthy adults

CHX chase assays showed that the SIRT7 T255E/S259E mutant (2E), which mimics the hyperphosphorylated state, seemed to be more stable than the WT, whereas SIRT7-2A, which mimics the hypophosphorylated state, underwent more rapid turnover than the WT (Fig

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Fluid Retention: GH promotes sodium and water retention