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Acknowledgments This work was supported by a grant from the Canadian Cancer Society (grant 2011-700751), and through support from B.r.a.i.n.child, the Wiley Fund and the Laurie Berman Fund for Brain Tumor Research.CF is a PhD candidate from The Programme for Advanced Medical Education, supported by FundaoGulbenkian, Fundao Champalimaud, Ministrio da Sade e Fundaopara a Cincia e Tecnologia, Portugal

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Many therapeutic protocols use doses of 1,0002,000 micrograms daily or weeklyhundreds of times the physiological requirementwithout adverse effects

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