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Advances in Genomics and Genetics

Glutathione antioxidant support for brighter-looking skin

In addition, DAMPs released during ferroptosis such as high mobility group box 1 (HMGB1) activate macrophages and Th17 cells, promoting the secretion of pro-inflammatory cytokines such as TNF-, IFN- and IL-17, thereby establishing a ferroptosis-inflammation positive feedback loop (see Figure 2 ) (109)