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Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis

Metabolomic studies on patients with PKU have demonstrated elevated serum levels of phenylalanine derivatives, including phenylpyruvate, phenylacetate, phenyllactate, mandelic acid, 4-hydroxyphenylacetic acid, and several others (56, 57)