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Collectively, our study establishes SYNCRIP as a central regulator that integrates transcriptional regulation, mRNA stability, and cap-independent translation to coordinate redox homeostasis and metabolic adaptation in GBM

Copper acts as a critical cofactor that allows the peptide complex to participate in biological signaling and enzymatic processes

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Protein bands were visualized using Immobilon Western Chemiluminescent HRP Substrate (Merck Millipore, Billerica, MA, USA) and a ChemiDoc MP Imaging System with Image Lab Touch Software Version 1.0 (Bio-Rad Laboratories, Hercules, CA, USA)