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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

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doi: 10.1038/s41467-020-19249-z

Continuous data collected from the participants over the 26 week treatment period was assessed using an ANCOVA model, using randomized treatment as a factor and baseline bodyweight as a covariate