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In addition, the relationship between inflammatory markers and brain structure in individuals with BD is well-known, both related to peripheral and central nervous system (CNS) inflammation (Fries et al., 2019)

However, HSP70s and HSP90s interact mainly via HSP70/HSP90 organizing protein (HOP) or CHIP (Evans et al., 2010

When an inflammatory process is triggered by the perturbation of tissue homeostasis, bone-marrow derived monocytes that circulate in the blood-stream are attracted to the site of inflammation, through a specific milieu of pro-inflammatory chemokines secreted by resident macrophages, stromal and endothelial cells