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In previous work, the Birsoy group showed that this mitochondrial membrane carrier regulates glutathione transport into mitochondria

*Correspondence: Xiaohong Xiang [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

One clue comes from the observation that activation of murine CD8 + T cells results in l-2HG accumulation, which leads to increased expression of CD62L, a selectin that permits lymph node recirculation, thus dictating cellular migration (125)