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The mechanism of dicoumarol-induced cell killing may not only be mediated via disruption of mitochondrial function and formation of ROS, but may also be related to suppression of the pro-survival response to the chemotherapy

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When dopamine levels decline, due to the death of dopaminergic cells, these messages no longer reach their destination, and so the regions of the brain that control movement no longer function properly

Details about the diffusion of the intervention into current health care practices in Ontario add an important dimension to the review