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Currently, velcade is used for the treatment of multiple myeloma because proteosome inhibition leads to increase level of IKB resulting (by preventing degradation) in the inhibition of NF-B ( is an FDA approved drug, an insight to repurpose this molecule against NGDs would be a viable approach

Using hydrophilic interaction liquid chromatography mass spectrometry 40 , 45,507 unique m/z analytes were detected in samples, of which 747 metabolites were identified using analytical standards

Picone P, Vilasi S, Librizzi F, Contardi M, Nuzzo D, Caruana L, et al

The diagnostic discrimination of cutaneous - synuclein deposition in Parkinson disease