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Schutz C, Davis AG, Sossen B, Lai RPJ, Ntsekhe M, Harley YXR, et al

Insights into the use of peripherally acting -opioid receptor antagonists (PAMORAs) in oncologic patients: from scientific evidence to real clinical practice

Actigraphic evidence and polysomnography studies have detected higher density of REM sleep, greater variability in sleep patterns, longer sleep latency and duration, lower sleep efficiency, greater number of arousals, fragmented sleep, and reduced daily activity, both in actively ill and remitted bipolar patients, relative to healthy controls (181184)