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Interestingly, the presence of iron rescued A431-B1 from the MDR-selective toxicity of Q4 (RR: 0.23 vs RR(Fe): 0.93) (Fig

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Inhibition of ME2 inhibitor-binding site mutants with MDSA or EA Based on the structures of ME2-EA and ME2-MDSA, we designed 16 ME2 mutants and assessed their susceptibility to MDSA or EA inhibition to determine which amino acid residues are required for MDSA or EA binding and inhibition (Fig